Promethazine hydrochloride tablets, USP are contraindicated in comatose states, and in folks regarded being hypersensitive or to possess experienced an idiosyncratic response to promethazine or to other phenothiazines.

Keep in mind that this medication has been prescribed for the reason that your doctor has judged which the benefit to you personally is bigger than the risk of Unwanted side effects. A lot of people using this medication would not have major Negative effects.

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It's not identified regardless of whether promethazine is distributed into milk. Because a lot of medications are distributed in human milk and due to probable for major adverse reactions to promethazine in nursing infants if it were distributed, a choice should be created irrespective of whether to discontinue nursing or even the drug, taking into account the value of the drug to the lady.

Since recurrences of NMS have already been reported with phenothiazines, the reintroduction of promethazine hydrochloride ought to be carefully considered.

Pregnancy Checks Diagnostic pregnancy exams depending on immunological reactions involving HCG and anti-HCG may perhaps bring about Bogus-adverse or Untrue-favourable interpretations.

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Promethazine hydrochloride tablets, USP should be utilized cautiously in people with cardiovascular disease or with impairment of liver operate.

A 2nd dose could be given eight–twelve several hours later on if important. Additional doses could website be presented on arising each morning and ahead of the night food for your length on the journey.

Although the drug can produce either CNS stimulation or CNS melancholy, CNS melancholy manifested by sedation is much more common with therapeutic doses more info of promethazine. The specific system of your CNS more info consequences with the drug is just not acknowledged. Promethazine also has antiemetic, anticholinergic, and local anesthetic consequences. In distinction to most other phenothiazines, promethazine also has an antimotion sickness motion, quite possibly due to a central anticholinergic effect on the vestibular apparatus along with the integrative vomiting Heart and medullary chemoreceptive set off zone in the midbrain.

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Fatal side effects can take place if you utilize codeine with alcohol, or with other medication that result in drowsiness, sedation or sluggish your respiration.